The article develops the notion of the ‘hyperabject’ – coined by Danish poet Theis Ørntoft – into a proper theoretical concept. The term hyperabject is a synthesis of Timothy Morton's concept of hyperobjects and Julia Kristeva's theory of abjection, and in the article we argue that the concept of the hyperabject entails a necessary critique of and correction to Morton's ecological thought, as well as various other versions of speculative realism, new materialism and object-oriented ontology.

Significant strides have been made in recent years towards understanding the molecular basis of cell cycle progression in the model bacterium Caulobacter crescentus. At the heart of cell cycle regulation is a multicomponent transcriptional feedback loop, governing the production of successive regulatory waves or pulses of at least three master regulatory proteins. These oscillating master regulators direct the execution of phase‐specific events and, importantly, through intrinsic genetic switches not only determine the length of a given phase, but also provide the (...) driving force that catapults the cell into the next stage of the cell cycle. The genetic switches act as fail safe mechanisms that prevent the cell cycle from relapsing and thus govern the ordered production and the periodicity of these regulatory waves. Here, we detail how the master regulators CtrA, GcrA and DnaA coordinate cell cycle progression and polar development in Caulobacter. BioEssays 28: 355–361, 2006. © 2006 Wiley Periodicals, Inc. (shrink)

With the outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), global researchers were confronted with major challenges. The German National Pandemic Cohort Network (NAPKON) was launched in fall 2020 to effectively leverage resources and bundle research activities in the fight against the coronavirus disease 2019 (COVID-19) pandemic. We analyzed the setup phase of NAPKON as an example for multicenter studies in Germany, highlighting challenges and optimization potential in connecting 59 university and nonuniversity study sites. We examined the ethics application (...) process of 121 ethics submissions considering durations, annotations, and outcomes. Study site activation and recruitment processes were investigated and related to the incidence of SARS-CoV-2 infections. For all initial ethics applications, the median time to a positive ethics vote was less than two weeks and 30 of these study sites (65%) joined NAPKON within less than three weeks each. Electronic instead of postal ethics submission (9.5 days (Q1: 5.75, Q3: 17) vs. 14 days (Q1: 11, Q3: 26), p value = 0.01) and adoption of the primary ethics vote significantly accelerated the ethics application process. Each study center enrolled a median of 37 patients during the 14-month observation period, with large differences depending on the health sector. We found a positive correlation between recruitment performance and COVID-19 incidence as well as hospitalization incidence. Our analysis highlighted the challenges and opportunities of the federated system in Germany. Digital ethics application tools, adoption of a primary ethics vote and standardized formal requirements lead to harmonized and thus faster study initiation processes during a pandemic. (shrink)

The placozoan Trichoplax adhaerens is a tiny hairy plate and more simply organized than any other living metazoan. After its original description by F.E. Schulze in 1883, it attracted attention as a potential model for the ancestral state of metazoan organization, the “Urmetazoon”. Trichoplax lacks any kind of symmetry, organs, nerve cells, muscle cells, basal lamina, and extracellular matrix. Furthermore, the placozoan genome is the smallest (not secondarily reduced) genome of all metazoan genomes. It harbors a remarkably rich diversity of (...) genes and has been considered the best living surrogate for a metazoan ancestor genome. The phylum Placozoa presently harbors three formally described species, while several dozen “cryptic” species are yet awaiting their description. The phylogenetic position of placozoans has recently become a contested arena for modern phylogenetic analyses and view‐driven claims. Trichoplax offers unique prospects for understanding the minimal requirements of metazoan animal organization and their corresponding malfunctions. (shrink)

The placozoan Trichoplax adhaerens has been bridging gaps between research disciplines like no other animal. As outlined in part 1, placozoans have been subject of hot evolutionary debates and placozoans have challenged some fundamental evolutionary concepts. Here in part 2 we discuss the exceptional genetics of the phylum Placozoa and point out some challenging model system applications for the best known species, Trichoplax adhaerens.

These remarks focus on Kraus’s claim that for Kant the category of substance cannot apply to the soul but that instead we can and should apply a merely regulative idea of the soul. While granting Kraus’s contention that we require an idea of the soul in order to investigate inner experience, I argue that the category of substance nonetheless applies to the soul, but that the notion of the soul as entirely non-corporeal is a regulative idea. To explore this contention, (...) I closely examine two crucial passages Kraus uses to argue against parity between inner and outer sense. (shrink)

This book addresses the logical aspects of the foundations of scientific theories. Even though the relevance of formal methods in the study of scientific theories is now widely recognized and regaining prominence, the issues covered here are still not generally discussed in philosophy of science. The authors focus mainly on the role played by the underlying formal apparatuses employed in the construction of the models of scientific theories, relating the discussion with the so-called semantic approach to scientific theories. The book (...) describes the role played by this metamathematical framework in three main aspects: considerations of formal languages employed to axiomatize scientific theories, the role of the axiomatic method itself, and the way set-theoretical structures, which play the role of the models of theories, are developed. The authors also discuss the differences and philosophical relevance of the two basic ways of aximoatizing a scientific theory, namely Patrick Suppes’ set theoretical predicates and the "da Costa and Chuaqui" approach. This book engages with important discussions of the nature of scientific theories and will be a useful resource for researchers and upper-level students working in philosophy of science. (shrink)

Elizabeth Jennings was one of the most popular, prolific, and widely anthologized lyric poets in the second half of the twentieth century. This first biography, based on extensive archival research and interviews with Jennings's contemporaries, integrates her life and work and explores the 'inward war' the poet experienced as a result of her gender, religion, and mental fragility. Originally associated with the Movement, Jennings was sui generis, believing poetry was 'communication' and 'communion.' She wrote of nature, friendship, childhood, religion, love, (...) and art, endearing her to a wide audience. Yet lifelong depression, unbearable loneliness, unrelenting fears, poverty, and physical illness plagued her. These were exacerbated by her gender in a male-dominated literary world and an inherited Catholic worldview which initially inculcated guilt and shame. However, a tenacious drive to be a poet made her, 'the most unconditionally loved writer of her generation.' Although her claim was that the poem is not the poet, her life is tracked in her voluminous published and unpublished poetry and prose. The themes of mental illness, the importance of place, the problems associated with being an unmarried woman artist, her relationship with literary mentors and younger poets, her non-feminist feminism, and her marginality and sympathy for the outcast are all explored. It was poetry which saved her; it helped her push back darkness and discover order in the midst of chaos. Poetry was her raison d'etre. It was her life. (shrink)

Coherence and correspondence are classical contenders as theories of truth. In this paper we examine them instead as interacting factors in the dynamics of belief across epistemic networks. We construct an agent-based model of network contact in which agents are characterized not in terms of single beliefs but in terms of internal belief suites. Individuals update elements of their belief suites on input from other agents in order both to maximize internal belief coherence and to incorporate ‘trickled in’ elements of (...) truth as correspondence. Results, though often intuitive, prove more complex than in simpler models (Hegselmann & Krause 2002, 2006; Grim, Singer, Reade & Fisher 2015). The optimistic finding is that pressures toward internal coherence can exploit and expand on small elements of truth as correspondence is introduced into epistemic networks. Less optimistic results show that pressures for coherence can also work directly against the incorporation of truth, particularly when coherence is established first and new data is introduced later. (shrink)

This is a volume containing papers honoring Patrick Suppes (1922-2014). All contributors have worked directly with Suppes or/and with his ideas. The book also contains one of the last papers by Suppes (co-authored by two of his collaborators). -/- The work of Suppes touches many different areas, ranging from meteorology to physics, through logic, mathematics, psychology, neuroscience, education, painting, but he was first of all and above all a philosopher, always questioning, but not in vain. There are not many (...) philosophers who can be proud of having written influential math textbooks, contributed decisively to the philosophical foundations of science, helped to develop research in real labs, promoted new forms o education (computer-assisted learning and the EGPY – Education Program for Gifted Youth). -/- Since the range of interest of Suppes was very broad, so is the variety of topics dealt with in this volume. The work of a researcher is certainly not limited to his own writings, but also has to be appreciated through the work of the people he has been working with and influenced. From this point of view the work of Suppes is very impressive, and the present book contributes to show that. -/- This is a follow up of a special issue of the journal Synthese, New Directions in the Foundations of Science, edited by Béziau and Krause, after a meeting they organized with Suppes in Florianópolis (Brazil) in 2002 for his 80th birthday. -/- Jean-Yves Béziau worked with Suppes at Stanford University for two years (2000 and 2001) and has been continuously working in the Suppes tradition of logic, methodology and philosophy of science, which emphasizes structures and models. -/- Décio Krause has used Suppes’ approach to the axiomatization of scientific theories in many fields. With J.C.M. Magalhães, he presented a ``Suppes predicate” for genetics and natural selection and with S. French he developed a Suppes predicate for quantum field theories via Fock spaces. (shrink)

During his long and continuing scholarly career, Patrick Suppes contributed significantly both to the sciences and to their philosophies. The volume consists of papers by an international group of Suppes colleagues, collaborators, and students in many of the areas of his expertise, building on or adding to his insights. Michael Friedman offers an overview of Suppes accomplishments and of his unique perspective on the relation between science and philosophy. Paul Humphreys, Stephen Hartmann, and Tom Ryckman present essays in the (...) philosophy of physics. Jens-Erik Fenstad, Harvey Friedman, and Jaako Hintikka consider problems in the foundations of mathematics, while the late Duncan Luce, Jean-Claude Falmagne, Brian Skyrms, and Hannes Leitgeb have contributed essays in theory of measurement, decision theory and probability. Foundations of economics and political theory are addressed by Adolfo Garcia de la Sienra, Russell Hardin, and Kenneth Arrow. Psychology, language, and philosophy of language are addressed by Elizabeth Loftus, Anne Fagot-Largeault, Willem Levelt, Dagfinn Follesdal, and Marcos Perreau-Guimares and some of Suppes most recent research in neurobiology is addressed in essays by Colleen Crangle, Acadio de Barros and Claudio Carvalhes. Finally Nancy Cartwright and Alexandre Marcelles consider the alignment (or misalignment) of method and policy. Each of the essays is accompanied by a response from Suppes.". (shrink)

In this paper, we present and defend an analysis of harm that we call the Negative Influence on Well-Being Account (NIWA). We argue that NIWA has a number of significant advantages compared to its two main rivals, the Counterfactual Comparative Account (CCA) and the Causal Account (CA), and that it also helps explain why those views go wrong. In addition, we defend NIWA against a class of likely objections, and consider its implications for several questions about harm and its role (...) in normative theorizing. (shrink)

Meaningful work is an important ideal, but it seems hard to give an adequate account of meaningful work. In this article, I conduct a revisionary conceptual analysis of ‘meaningful work’, i.e. a conceptual analysis that aims at finding a better and more useful way to use this term. I argue for a distinction between cases where work itself is meaningful and cases where other sources of meaning are found at work. The term ‘meaningful work’ is most useful for the former (...) cases. I then argue for the reasons account of what makes work itself meaningful: work is meaningful if (and to the extent that) there are good reasons to do it. I compare this to established accounts of meaningful work, such as subjective meaningfulness, self-realization, alienation, the unity of conception and execution, autonomy, social contribution, and Veltman’s four-dimensional account. None of these capture the distinct concern that the concept ‘meaningful work’ should capture, or they do so less well than the reasons account. This also shows that work can be meaningful regardless of whether it is good in other respects, such as in inherent interest or opportunities for self-realization. (shrink)

Extensions of traditional syllogistics have been increasingly researched in philosophy, linguistics, and areas such as artificial intelligence and computer science in recent decades. This is mainly due to the fact that syllogistics is seen as a logic that comes very close to natural language abilities. Various forms of extended syllogistics have become established. This paper deals with the question to what extent a syllogistic representation in CL diagrams can be seen as a form of extended syllogistics. It will be shown (...) that the ontology of CL enables numerically exact assertions and inferences. (shrink)

In early modernity, one can find many spatial logic diagrams whose geometric forms share a family resemblance with religious art and symbols. The family resemblance these diagrams bear in form is often based on a vesica piscis or on a cross: Both logic diagrams and spiritual symbols focus on the intersection or conjunction of two or more entities, e.g. subject and predicate, on the one hand, or god and man, on the other. This paper deals with the development and function (...) of logic diagrams, their analogy to religious art and symbols, and their modern application in artificial intelligence. (shrink)

_"One of the most important political books of 2018."—Rod Dreher, ___American Conservative__ Of the three dominant ideologies of the twentieth century—fascism, communism, and liberalism—only the last remains. This has created a peculiar situation in which liberalism’s proponents tend to forget that it _is _an ideology and not the natural end-state of human political evolution. As Patrick Deneen argues in this provocative book, liberalism is built on a foundation of contradictions: it trumpets equal rights while fostering incomparable material inequality; its (...) legitimacy rests on consent, yet it discourages civic commitments in favor of privatism; and in its pursuit of individual autonomy, it has given rise to the most far-reaching, comprehensive state system in human history. Here, Deneen offers an astringent warning that the centripetal forces now at work on our political culture are not superficial flaws but inherent features of a system whose success is generating its own failure. (shrink)

The emergentist position that R. Keith Sawyer has formulated, nonreductive individualism, contains three propositions. First, that social characteristics must always be realized in individuals; second, that it is nevertheless possible to understand social properties as irreducible; and third, that therefore it is possible to demonstrate how social properties are able to exercise independent causal influences on individuals and their properties. It is demonstrated that Sawyer is not able to meet an objection that Kim has formulated against the analogous position in (...) the philosophy of mind. In his defense of the claim of irreducibility Sawyer refers to Fodor’s argument about multiple realizability, but this line of argument cannot preserve the claim for downward causation because Fodor’s claim for irreducibility rests on assumptions that are not compatible with a systematic formulation of downward causation. The article proposes a reading of Fodor’s argument that is consistent with individualism but not with nonreductive individualism. (shrink)

In this paper, we interpret a 19th century diagram, which is meant to visualise G.W.F. Hegel’s entire method of the `Science of Logic' on the basis of bitwise operations. For the interpretation of the diagram we use a binary numeral system, and discuss whether the anti-Hegelian argument associated with it is valid or not. The reinterpretation is intended to make more precise rules of construction, a stricter binary code and a review of strengths and weaknesses of the critique.

Quarantine and spatial distancing measures associated with COVID-19 resulted in substantial changes to individuals’ everyday lives. Prominent among these lifestyle changes was the way in which people interacted with media—including music listening. In this repeated assessment study, we assessed Australian university students’ media use throughout early stages of the COVID-19 pandemic in Australia, and determined whether media use was related to changes in life satisfaction. Participants were asked to complete six online questionnaires, capturing pre- and during-pandemic experiences. The results indicated (...) that media use varied substantially throughout the study period, and at the within-person level, life satisfaction was positively associated with music listening and negatively associated with watching TV/videos/movies. The findings highlight the potential benefits of music listening during COVID-19 and other periods of social isolation. (shrink)

In the year 1714, Johann Christian Lange published a baroque textbook about a logic machine, supposed to simulate human cognitive abilities such as perception, judgement, and reasoning. From today’s perspective, it can be argued that this blueprint is based on an inference engine applied to a strict ontology which serves as a knowledge base. In this paper, I will first introduce Lange’s approach in the period of baroque logic and then present a diagrammatic modernization of Lange’s principles, entitled Calculus CL. (...) Finally, I would like to discuss the possibilities of how to apply CL to modern cases of concern by using an example from epidemiology. (shrink)

The mechanistic view of computation contends that computational explanations are mechanistic explanations. Mechanists, however, disagree about the precise role that the environment – or the so-called “contextual level” – plays for computational explanations. We advance here two claims: Contextual factors essentially determine the computational identity of a computing system ; this means that specifying the “intrinsic” mechanism is not sufficient to fix the computational identity of the system. It is not necessary to specify the causal-mechanistic interaction between the system and (...) its context in order to offer a complete and adequate computational explanation. While the first claim has been discussed before, the second has been practically ignored. After supporting these claims, we discuss the implications of our contextualist view for the mechanistic view of computational explanation. Our aim is to show that some versions of the mechanistic view are consistent with the contextualist view, whilst others are not. (shrink)

The mechanistic view of computation contends that computational explanations are mechanistic explanations. Mechanists, however, disagree about the precise role that the environment – or the so-called “contextual level” – plays for computational explanations. We advance here two claims: Contextual factors essentially determine the computational identity of a computing system ; this means that specifying the “intrinsic” mechanism is not sufficient to fix the computational identity of the system. It is not necessary to specify the causal-mechanistic interaction between the system and (...) its context in order to offer a complete and adequate computational explanation. While the first claim has been discussed before, the second has been practically ignored. After supporting these claims, we discuss the implications of our contextualist view for the mechanistic view of computational explanation. Our aim is to show that some versions of the mechanistic view are consistent with the contextualist view, whilst others are not. (shrink)

This work is a systematic investigation of a range of solutions offered today for the philosophical problem of mental causation. The premises constituting the problem are analyzed before a survey is developed of the most popular theories on mental causation. It is demonstrated in detail why most of these canonical solutions must be considered deficient. In a third part, the 'new compatibilist's' approach to mental causation is explored, which is characterized by assertion of a non-identity-but-non-distinctness principle. The last part aims (...) to offer an alternative solution to the problem. On the basis of a certain set of counterfactual conditionals, which are jointly taken to provide a definition of 'causal proportionality' that improves the existing definitions, it is shown that a specific, and hitherto widely neglected, version of causal overdeterminationism must be considered the most successful solution to the problem of mental causation. (shrink)

The literature on quantum logic emphasizes that the algebraic structures involved with orthodox quantum mechanics are non distributive. In this paper we develop a particular algebraic structure, the quasi-lattice ( $${\mathfrak{I}}$$ -lattice), which can be modeled by an algebraic structure built in quasi-set theory $${\mathfrak{Q}}$$. This structure is non distributive and involve indiscernible elements. Thus we show that in taking into account indiscernibility as a primitive concept, the quasi-lattice that ‘naturally’ arises is non distributive.

The mechanistic view of computation contends that computational explanations are mechanistic explanations. Mechanists, however, disagree about the precise role that the environment – or the so-called “contextual level” – plays for computational explanations. We advance here two claims: Contextual factors essentially determine the computational identity of a computing system ; this means that specifying the “intrinsic” mechanism is not sufficient to fix the computational identity of the system. It is not necessary to specify the causal-mechanistic interaction between the system and (...) its context in order to offer a complete and adequate computational explanation. While the first claim has been discussed before, the second has been practically ignored. After supporting these claims, we discuss the implications of our contextualist view for the mechanistic view of computational explanation. Our aim is to show that some versions of the mechanistic view are consistent with the contextualist view, whilst others are not. (shrink)

A recent approach to the problem of logical omniscience holds that belief is question-sensitive: what an agent believes depends on what question they try to answer (Pérez Carballo, 2016; Yalcin, 2018; Hoek, 2022). While the question-sensitive approach can avoid some logical omniscience problems, we argue that it suffers from nearby problems. First, these accounts all validate closure principles that are just as implausible as the ones it was designed to avoid. Second, question-sensitivity by itself isn’t suitable for explaining many kinds (...) of failures of logical omniscience. Recognizing the flaws of this approach, however, naturally leads to a more promising solution. Our account generalizes the question-sensitive approach by appealing to (1) the defeasible nature of dispositions toward action associated with belief and (2) the algorithms an agent uses to make decisions. On our view, then, believing that φ means being disposed to employ an algorithm which outputs acting on the information that φ in normal circumstances associated with φ. We argue that this account naturally generalizes the question-sensitive accounts while avoiding their faults. (shrink)

In recent years CL diagrams inspired by Lange’s Cubus Logicus have been used in various contexts of diagrammatic reasoning. However, whether CL diagrams can also be used as a formal system seemed questionable. We present a CL diagram as a formal system, which is a fragment of propositional logic. Syntax and semantics are presented separately and a variant of bitstring semantics is applied to prove soundness and completeness of the system.

This paper develops a formal framework to model a process in which the formation of individual opinions is embedded in a deliberative exchange with others. The paper opts for a low-resolution modeling approach and abstracts away from most of the details of the social-epistemic process. Taking a bird's eye view allows us to analyze the chances for the truth to be found and broadly accepted under conditions of cognitive division of labour combined with a social exchange process. Cognitive division of (...) labour means that only some individuals are active truth seekers, possibly with different capacities. Both mathematical tools and computer simulations are used to investigate the model. As an analytical result, the Funnel Theorem states that under rather weak conditions on the social process, a consensus on the truth will be reached if all individuals possess an arbitrarily small capacity to go for the truth. The Leading the pack Theorem states that under certain conditions even a single truth seeker may lead all individuals to the truth. Systematic simulations analyze how close agents can get to the truth depending upon the frequency of truth seekers, their capacities as truth seekers, the position of the truth (more to the extreme or more in the centre of an opinion space), and the willingness to take into account the opinions of others when exchanging and updating opinions. (shrink)

H. Post's conception of quantal particles as non-individuals is set in a formal logico-mathematical framework. By means of this approach certain metaphysical implications of quantum mechanics can be further explored.

In this paper I consider some logical and mathematical aspects of the discussion of the identity and individuality of quantum entities. I shall point out that for some aspects of the discussion, the logical basis cannot be put aside; on the contrary, it leads us to unavoidable conclusions which may have consequences in how we articulate certain concepts related to quantum theory. Behind the discussion, there is a general argument which suggests the possibility of a metaphysics of non-individuals, based on (...) a reasonable interpretation of quantum basic entities. I close the paper with a suggestion that consists in emphasizing that quanta should be referred to by the cardinalities of the collections to which they belong, for which an adequate mathematical framework seems to be possible. (shrink)

While “green marketing” has emerged as powerful competitive force, many markets lack clear institutional standards or knowledgeable customers to allow firms committed to sustainable practices to differentiate themselves from opportunistic, green-washing competitors. Within these contexts we propose a firm-level lens based on authentic firm reputation as an important, yet poorly understood, competitive force. Drawing on interview data from the architectural design services context we identify the elements that firms use to communicate their own authenticity, as well as discourage green-washing behavior (...) of peers, and present these elements as the “Diamond” model of authentic green marketing, consisting of: The ability to appear above commercial considerations; The ability to frame production methods as craft; The use of corporate visual identity; and An organization's social network of stakeholders. We conclude by discussing the generalizability and implications of our framework for practitioners as well as opportunities for future research. (shrink)

Medical, psychological, educational and social interventions to modify the behaviour of autistic people are only justified if they confer benefit on those people. However, it is not clear how ‘benefit’ should be understood. Most such interventions are justified by referring to the prospect that they will effect lasting improvements in the well-being and happiness of autistic people, so they can lead good lives. What does a good life for an autistic person consist in? Can we assume that his or her (...) well-being is substantively the same as the well-being of non-autistic individuals? In this paper, we argue that, as it stands, the current approach to the study of well-being is for the most part unable to answer these questions. In particular, much effort is needed in order to improve the epistemology of well-being, especially so if we wish this epistemology to be ‘autism-sensitive’. Towards the end of the paper, we sketch a new, autism-sensitive approach and apply it in order to begin answering our initial questions. (shrink)

From the mid-1600s to the beginning of the eighteenth century, there were two main circles of German scholars which focused extensively on diagrammatic reasoning and representation in logic. The first circle was formed around Erhard Weigel in Jena and consists primarily of Johann Christoph Sturm and Gottfried Wilhelm Leibniz; the second circle developed around Christian Weise in Zittau, with the support of his students, particularly Samuel Grosser and Johann Christian Lange. Each of these scholars developed an original form of using (...) geometric diagrams in logic. In this paper, I will trace the historical notes of John Venn and other modern logicians back to the original works published in the Weigel and Weise circles and describe the development of using geometric figures for logical reasoning and representation in that period of time. (shrink)

The paper examines Schopenhauer’s complex diagrams from the Berlin Lectures of the 1820 s, which show certain partitions of classes. Drawing upon ideas and techniques from logical geometry, we show that Schopenhauer’s partition diagrams systematically give rise to a special type of Aristotelian diagrams, viz. (strong) α -structures.